Mutation rate from methodologies that examine sequence data from genes

Range 1.3×10^−8 to 1.8×10^−8 mutation/base/generation
Organism Human Homo sapiens
Reference Veeramah KR, Hammer MF. The impact of whole-genome sequencing on the reconstruction of human population history. Nat Rev Genet. 2014 Mar15(3):149-62. doi: 10.1038/nrg3625. p.154 box 2 bottom sentencePubMed ID24492235
Primary Source Lynch, M. Rate, molecular spectrum, and consequences of human mutation. Proc. Natl Acad. Sci. USA 107, 961–968 (2010). doi: 10.1073/pnas.0912629107. & Nelson, M. R. et al. An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science 337, 100–104 (2012). doi: 10.1126/science.1217876.PubMed ID20080596, 22604722
Comments p.154 box 2 bottom sentence:"Interestingly, estimates from alternative population genetic methodologies that examine sequence data from genes [primary sources] are intermediate (that is, 1.3–1.8 × 10-8 per base per generation) to current pedigree-based [BNID 110292, 105919] and phylogenetic [BNID 100414] estimates, which suggests that the true value lies in this range."
Entered by Uri M
ID 111584