Rate of fast orthograde axonal transport in motoneurones of the sciatic nerve

Value 14 mm/hour Range: ±0.9 Table - link mm/hour
Organism Rat Rattus norvegicus
Reference Whiteley SJ, Townsend J, Tomlinson DR, Brown AM. Fast orthograde axonal transport in sciatic motoneurones and nerve temperature in streptozotocin-diabetic rats. Diabetologia. 1985 Nov28(11):847-51. abstract & p.849 table 1PubMed ID2417904
Method Abstract:"This study measured the velocity of fast orthograde axonal transport of incorporated 3H-proline in motoneurones of the sciatic nerve in control rats and in rats with streptozotocin-induced diabetes of 3 weeks duration. Sciatic nerve and abdominal cavity temperatures were monitored throughout the period of measurement of transport velocity, and the rats were warmed to minimise hypothermia at both sites."
Comments Abstract:"The velocities of orthograde axonal transport for the fastest molecules containing 3H-proline were 14.0±0.9 (SEM)mm/h for controls and 13.9±1.1 (SEM)mm/h for diabetic rats." P.849 right column bottom paragraph: "Axonal transport: The four grouped profiles describing the distribution of activity along the nerve are shown in Figure 1, and the velocities and distances are given in Table 1. These data show that there were no significant differences in either peak distance or in peak front distance between diabetic and control rats at either survival time. Accordingly, the calculated velocities for the peaks and peak fronts were also similar in both groups of rats."
Entered by Uri M
ID 112231