Half-lives of clearance rates in rhesus macaque

Range 3 - 4 min
Organism SIV
Reference De Boer RJ, Ribeiro RM, Perelson AS. Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. PLoS Comput Biol. 2010 Sep 2 6(9):e1000906. doi: 10.1371/journal.pcbi.1000906. p.1 right column bottom paragraph & p.3 left column 2nd paragraphPubMed ID20824126
Primary Source [16] Zhang L, Dailey PJ, He T, Gettie A, Bonhoeffer S, et al. (1999) Rapid clearance of simian immunodeficiency virus particles from plasma of rhesus macaques. J Virol 73: 855–860. [17] Zhang L, Dailey PJ, Gettie A, Blanchard J, Ho DD (2002) The liver is a major organ for clearing simian immunodeficiency virus in rhesus monkeys. J Virol 76: 5271–5273.PubMed ID9847402, 11967341
Comments P.1 right column bottom paragraph: "Viral clearance rates have been estimated in the blood, and different techniques have yielded a variety of estimates [refs 4,15, primary sources]. Rapid clearance rates with half-lives of 3–4 minutes were found after infusion of SIV into the blood of uninfected and infected rhesus macaques [primary sources]."
Entered by Uri M
ID 112645