Number of virions per infected peripheral blood mononuclear cell (PBMC) in macaque

Range ~5×10^4 (1.4×10^4 – 1.2×10^5) virions per infected cell
Organism SIV
Reference De Boer RJ, Ribeiro RM, Perelson AS. Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. PLoS Comput Biol. 2010 Sep 2 6(9):e1000906. doi: 10.1371/journal.pcbi.1000906. p.2 right column 2nd paragraphPubMed ID20824126
Primary Source [24] Chen HY, Di Mascio M, Perelson AS, Ho DD, Zhang L (2007) Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques. Proc Natl Acad Sci USA 104: 19079–19084.PubMed ID18025463
Method P.2 right column 2nd paragraph: "Finally, the most direct estimates for the total amount of virus produced per infected cell was achieved using single-cycle SIV to infect PBMC which were placed back in uninfected rhesus macaques."
Comments P.2 right column 2nd paragraph: "By measuring the total amount of virus produced and accounting for clearance, this experiment yielded a total production of approximately 5×10^4 (range 1.4×10^4–1.2×10^5) virions per infected cell [primary source]. Because productively infected cells have a lifespan of about one day, the cellular burst size estimates of Chen et al. [primary source] imply daily production rates of approximately 5×10^4 virions."
Entered by Uri M
ID 112648