productively infected CD4+ T cells 10^8 cells: total number of HIV-1 particles >5×10^10 particles
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||P.1 left column top paragraph: "Introduction: The major targets of HIV and simian immunodeficiency virus (SIV) infection are CD4+ T cells [ref 1]. During the acute stage of infection large numbers of resting and memory CD4+ T cells disappear from the lymphoid tissues and mucosal layers,
particularly in the gut, by direct infection and by bystander effects. Lymphoid tissue remains the primary site of infection after acute infection has resolved and the viral load approaches a steady state called the ‘‘set-point’’ [ref 1]. Chronic infection is characterized by a set-point viral load, and rapid turnover of productively infected cells [refs 2–4]. To maintain this steady state requires a balance between virus production and clearance, and between
target cell production and death. Combining image analysis with in situ hybridization in lymphoid tissue from patients chronically infected with HIV-1, the total number of productively infected CD4+ T cells has been estimated to be 10^8 cells, and the total number of HIV-1 particles has been estimated to exceed 5×10^10 virions [primary sources]. At steady state, one could naively conclude that a
single productively infected CD4+ T cell should therefore account for a viral load of approximately 500 virions. [Investigators] shall show below that the situation is more complex."