Fraction of oxidoreductases that require a coenzyme

Range >80 %
Organism Generic
Reference Hartl J, Kiefer P, Meyer F, Vorholt JA. Longevity of major coenzymes allows minimal de novo synthesis in microorganisms. Nat Microbiol. 2017 May 15 2 :17073. doi: 10.1038/nmicrobiol.2017.73 p.1 left column top paragraphPubMed ID28504670
Primary Source [1] Fischer, J. D., Holliday, G. L., Rahman, S. A. & Thornton, J. M. The structures and physicochemical properties of organic cofactors in biocatalysis. J. Mol. Biol. 403, 803–824 (2010) doi: 10.1016/j.jmb.2010.09.018PubMed ID20850456
Comments P.1 left column top paragraph: "A large proportion of enzymes depend on organic cofactors to enlarge the biochemical potential of cellular metabolism that can be generated by proteins alone [primary source]. In fact, all enzyme classes harbour members that depend on organic cofactors, with oxidoreductases being the most prominent representative, as more than 80% of these enzymes require coenzymes such as nicotinamide adenine dinucleotide (NAD)[primary source]. Unlike most metabolites, coenzymes mainly act catalytically, and their configurations revert back to the original state, usually via a second enzymatic reaction (for example, in redox reactions). This is known as ‘catalytic turnover’ and typically occurs at a high rate."
Entered by Uri M
ID 113853