≤3 orders of magnitude
||Bar-Even A. et al., The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters. Biochemistry. 2011 May 31 50(21):4402-10. doi: 10.1021/bi2002289. p.4403 right column top paragraphPubMed ID21506553
|| Wright, B. E., Butler, M. H., and Albe, K. R. (1992) Systems analysis of the tricarboxylic acid cycle in Dictyostelium discoideum . I. The basis for model construction. J. Biol. Chem. 267, 3101 – 3105.PubMed ID1737766
||"Here [investigators] describe a global view of enzyme parameters
with the aim of highlighting the forces that shape the catalytic
efficiency of enzymes."
||"Further, most parameters in the literature are measured in vitro, which can be considerably different from those measured in vivo. [refs 32,33] These differences can be as great as 3 orders of magnitude. [primary source]"