Divergence rate for protein coding mitochondrial DNA

Range 0.32 - 2.5 substitutions/site/Myr
Organism Human Homo sapiens
Reference Peterson GI, Masel J. Quantitative prediction of molecular clock and ka/ks at short timescales. Mol Biol Evol. 2009 Nov26(11):2595-603. doi: 10.1093/molbev/msp175. p.2595 left column 3rd paragraphPubMed ID19661199
Primary Source Parsons TJ, Muniec DS, Sullivan K, et al. 1997. A high observed substitution rate in human mitochondrial DNA control region. Nat Genet. 15: 363–368. DOI: 10.1038/ng0497-363 AND Sigurdard´ottir S, Helgason A, Gulcher JR, Steffansson K, Donnely P. 2000. The mutation rate in human mtDNA control region. Am J Hum Genet. 66: 1599–1609. AND Howell N, Smejkal CB, Mackey DA, Chinnery PF, Turnbull DM, Hernstadt C. 2003. The pedigree rate of sequence divergence in the human mitochondrial genome: there is a difference between phylogenetic and pedigree rates. Am J Hum Genet. 72: 659–670. DOI: 10.1086/368264PubMed ID9090380, 10756141, 12571803
Comments P.2595 left column 3rd paragraph: "Using mitochondrial DNA (mtDNA) taken from human pedigrees, several investigators have estimated divergence rates that are many times greater than the accepted rate estimates for animal species (Ho et al. 2005). In contrast to the accepted rate of 0.02 substitutions/site/Myr for protein-coding mtDNA in mammals (BNID 113217) and birds (BNID 113217), these studies found rates between 0.32 and 2.5 substitutions/site/Myr (primary sources Parsons et al. 1997, Sigurdardóttir et al. 2000, Howell et al. 2003). In addition, in a study using well-preserved Antarctic subfossil bones, Lambert et al. (BNID 113219) estimated a divergence rate of 0.95 substitutions/site/Myr in Adélie penguins."
Entered by Uri M
ID 113218