| Comments |
P.1065 left column 4th paragraph: "Ceramides are amide-linked fatty acids containing a long-chain amino alcohol called sphingoid base and account for 30 to 40% of SC lipids. Ceramides are generated by serine-palmitoyl transferase as rate-limiting enzyme and by hydrolysis of both glucosylceramide (by β-glucocerebrosidase) (ref 25) and sphingomyelin (by acid sphingomyelinase) (ref 26). The SC contains at least nine different free ceramides (ref 27), two of which are ceramide A and ceramide B, covalently bound to cornified envelope proteins, most importantly to involucrin (ref 28)." |