Fraction of protein mass of mammalian epidermis that keratins and filaggrin constitute

Range 80-90 %
Organism Mammals
Reference Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008 Dec17(12):1063-72. p.1064 left columnPubMed ID19043850
Primary Source [3] Roop D. Defects in the barrier. Science 1995: 267: 474–475. [4] Nemes Z, Steinert P M. Bricks and mortar of the epidermal barrier. Exp Mol Med 1999: 31: 5–19. DOI: 10.1038/emm.1999.2PubMed ID7529942, 10231017
Comments P.1063 right column bottom paragraph to p.1064 left column: "Corneocytes: During the final stages of normal differentiation, keratins are aligned into highly ordered and condensed arrays through interactions with filaggrin, a matrix protein. The role of filaggrin in skin barrier homeostasis is only partially known. Filaggrin aggregates the keratin filaments into tight bundles. This promotes the collapse of the cell into a flattened shape, which is characteristic of corneocytes in the cornified layer (ref 2). Together, keratins and filaggrin constitute 80–90% of the protein mass of mammalian epidermis (primary sources). The importance of filaggrin for epidermal barrier homeostasis is indicated in mouse models and human diseases with aberrant expression of this protein, ichthyosis vulgaris and atopic dermatitis (refs 2,5,6)."
Entered by Uri M
ID 113171