The fraction of a bolus injection of SIV going into an organ after two hours, and the clearance rate in that organ in macaque

Range Table - link
Organism SIV
Reference De Boer RJ, Ribeiro RM, Perelson AS. Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. PLoS Comput Biol. 2010 Sep 2 6(9):e1000906. doi: 10.1371/journal.pcbi.1000906. p.3 table 1PubMed ID20824126
Primary Source [16] Zhang L, Dailey PJ, He T, Gettie A, Bonhoeffer S, et al. (1999) Rapid clearance of simian immunodeficiency virus particles from plasma of rhesus macaques. J Virol 73: 855–860. [17] Zhang L, Dailey PJ, Gettie A, Blanchard J, Ho DD (2002) The liver is a major organ for clearing simian immunodeficiency virus in rhesus monkeys. J Virol 76: 5271–5273.PubMed ID9847402, 11967341
Method See notes beneath table
Comments P.3 right column 3rd paragraph: "Using the estimated clearance rate from the blood of 0.2 min^-1 [primary source 17] as the efflux rate, e=288 d^-1, [investigators] estimate the fraction, f , and the clearance in the organ, cO, from the Zhang et al. [primary source 17] data shown in Table 1. Since in Eq. (4) the term e^(-288×(2/24))≈0, the fraction of measured radioactivity in the organ, RO, determines the parameter f in the model. Substituting the fraction of SIV RNA in the organ, VO/VP(0), the estimated efflux, e, and the fraction of radioactivity, RO, into Eq. (3), one can numerically solve for the clearance rate constants, cO, in the four organs (Table 1). The estimated clearance rates in the various organs vary from cO≈80 d^-1 in the liver to cO≈10 d^-1 in the lymph nodes. The latter is only 2-fold faster than the clearance rate of c=5.5 d^-1 estimated by Reilly et al. [BNID 112649, ref 23] for lymphoid tissue."
Entered by Uri M
ID 112650