Percent of genes for which stability is estimated to control the mRNA level

Range 5-10 %
Organism Human Homo sapiens
Reference Sharova LV, Sharov AA, Nedorezov T, Piao Y, Shaik N, Ko MS. Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res. 2009 Feb16(1):45-58.PubMed ID19001483
Primary Source Bolognani F, Perrone-Bizzozero NI. RNA-protein interactions and control of mRNA stability in neurons. J Neurosci Res. 2008 Feb 1586(3):481-9PubMed ID17853436
Comments Post-transcriptional regulation of gene expression includes mRNA processing, splicing, editing, transport, stability and translation. Degradation of mRNA is an important component of gene function that controls the steady-state concentration of functional transcript levels in the cell. In human mRNA, stability is estimated to control the mRNA level of about 5–10% of all genes. The rate of mRNA decay is regulated by the interaction of cis-acting elements in the transcripts and sequence-specific RNA-binding proteins.
Entered by Uri M
ID 104216