||Human Homo sapiens
||Chiaromonte F, Miller W, Bouhassira EE. Gene length and proximity to neighbors affect genome-wide expression levels. Genome Res. 2003 Dec13(12):2602-8.PubMed ID14613975
||Reasearchers adopted a simple definition of urban genes as the 25% of the MHKT (minimal housekeeping transcriptome) genes with the shortest distance to their closest neighbor, regardless of orientation. Rural genes are defined as the remaining 75%. The tables in Figure 4 report mean and median distances to closest neighbors, as well as mean mRNA/cell and mean ln(mRNA/cell), with their standard errors, for genes in the two classes. The mean expression level for the urban class is almost twofold lower than for the rural class (62.2 ± 7.58 and 110.8 ± 10.1 mRNA/cell, respectively).
||The most novel and striking result from analyses is the negative association between mRNA expression and distance to the closest neighboring gene, because it indicates that transcriptional interference plays a role in determining the level of gene expression.