Fraction of genome that is estimated to be controlled by miRNA

Range ~0.5 of the genome
Organism Human Homo sapiens
Reference Sonenberg N, Hinnebusch AG. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell. 2009 Feb 20 136(4):731-45.PubMed ID19239892
Comments It is estimated that approximately half of the human genome is controlled by miRNAs, as there are ~1,000 miRNAs and each could control ~10 mRNAs (assuming there are ~20,000 genes). For ~60% of genes (in many and perhaps all metazoans) regulated by miRNA see PMID 19901979 p.1 left column
Entered by Uri M
ID 107555