Median number of proteins translated per mRNA

Value 9800 proteins/mRNA
Organism Mouse Mus musculus
Reference Li et al. (2014), System wide analyses have underestimated protein abundances and the importance of transcription in mammals. PeerJ 2:e270 DOI 10.7717/peerj.270 p.7 bottom paragraphPubMed ID24688849
Method "Western blot and SILAC mass spectrometry measurements"
Comments "For [researchers'] corrected data, the median number of proteins translated per mRNA is 9,800 compared to Schwanhausser et al.'s (2011) original estimate of 900 and their second estimate of 2,800. In yeast, the ratio of protein molecules translated per mRNA is 4,200-5,600 (Ghaemmaghami et al., 2003 Lu et al., 2007 BNID 104745, 104185). Given that mammalian cells have a higher protein copy number than yeast (Milo et al., 2010), it is not unreasonable that the ratio in mammalian cells would be higher."
Entered by Uri M
ID 110236