Radius of diffusion channel of nuclear pore complex (NPC)

Value 2.6 nm
Organism Human Homo sapiens
Reference Mohr D, Frey S, Fischer T, Güttler T, Görlich D. Characterisation of the passive permeability barrier of nuclear pore complexes. EMBO J. 2009 Sep 2 28(17):2541-53.PubMed ID19680228
Method In this study researchers used a size series of 11 inert permeation probes with masses between 0.6 and 40 kDa to explore the permeability barrier of NPCs. The data obtained suggest a sieve-like barrier with a heterogeneous mesh size and a prevalent mesh radius of ˜2.6 nm. Researchers used permeabilized HeLa cells.
Comments This is far more narrow than the earlier assumed 4.5 nm (Paine et al, 1975 Keminer and Peters, 1999 BNID 104250).
Entered by Uri M
ID 105654