Increase in pituitary DNA content and total pituitary cell number above euthyroid values 15 days after thyroidectomy

Range 30 - 40 % above euthyroid values
Organism Rat Rattus norvegicus
Reference DeFesi CR, Astier HS, Surks MI. Kinetics of thyrotrophs and somatotrophs during development of hypothyroidism and L-triiodothyronine treatment of hypothyroid rats. Endocrinology. 1979 Apr104(4):1172-80 DOI: 10.1210/endo-104-4-1172 abstractPubMed ID436756
Method Abstract: "Two experiments were performed to assess the kinetics of changes in somatotroph (St) and thyrotroph (Tt) populations in the rat anterior pituitary after thyroidectomy and during T3 treatment (10 µg/100 g BW) of thyroidectomized rats. St and Tt numbers were determined by a method combining cell counting and determination of DNA in dispersed cells as well as the percentage distribution of cells at the electron microscopic level."
Comments Abstract: "Both pituitary DNA content and total pituitary cell number increased 30-40% above euthyroid values after 15 days."
Entered by Uri M
ID 115298