Decrease in fraction of TSH [Thyroid-stimulating hormone] cell number after thyroidectomy

Range 2.7 - 3.9 %/day
Organism Rat Rattus norvegicus
Reference DeFesi CR, Astier HS, Surks MI. Kinetics of thyrotrophs and somatotrophs during development of hypothyroidism and L-triiodothyronine treatment of hypothyroid rats. Endocrinology. 1979 Apr104(4):1172-80 DOI: 10.1210/endo-104-4-1172 p.1179 left column 3rd paragraphPubMed ID436756
Method Abstract: "Two experiments were performed to assess the kinetics of changes in somatotroph (St) and thyrotroph (Tt) populations in the rat anterior pituitary after thyroidectomy and during T3 treatment (10 µg/100 g BW) of thyroidectomized rats. St and Tt numbers were determined by a method combining cell counting and determination of DNA in dispersed cells as well as the percentage distribution of cells at the electron microscopic level."
Comments P.1179 left column 3rd paragraph: "A similar analysis of the decrease in TSH cells that occurred during treatment of Tx [thyroidectomized] rats with T3 suggested that the number of these cells decreased at a rate between 2.7-3.9%/day and that this rate was significantly greater than that of St. Similar to St, the rate of decrease in Tt [thyrotrdph] and TE [Thyroidectomy] cell numbers seemed relatively constant during T3 [10 µg/100 g BW] treatment despite the fact that the rats were initially hypothyroid, passed through the euthyroid state, and were hyperthyroid at the end of the experiment."
Entered by Uri M
ID 115302