Decrease in fraction of somatotroph cell number after thyroidectomy

Range 1.16 - 1.29 %/day
Organism Rat Rattus norvegicus
Reference DeFesi CR, Astier HS, Surks MI. Kinetics of thyrotrophs and somatotrophs during development of hypothyroidism and L-triiodothyronine treatment of hypothyroid rats. Endocrinology. 1979 Apr104(4):1172-80 DOI: 10.1210/endo-104-4-1172 p.1179 left column 2nd paragraphPubMed ID436756
Method Abstract: "Two experiments were performed to assess the kinetics of changes in somatotroph (St) and thyrotroph (Tt) populations in the rat anterior pituitary after thyroidectomy and during T3 treatment (10 µg/100 g BW) of thyroidectomized rats. St and Tt numbers were determined by a method combining cell counting and determination of DNA in dispersed cells as well as the percentage distribution of cells at the electron microscopic level."
Comments P.1179 left column 2nd paragraph: "The present studies show that the large decrease in the number of St [somatotroph] after thyroidectomy did not occur rapidly upon establishing the hypothyroid state. This change in St number seemed best described as a decrease at a constant fractional rate, between 1.16-1.29%/day in the two experiments."
Entered by Uri M
ID 115301