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Proportion of natural MHC class II ligands that are derived from cytosolic and nuclear proteins

Range	≤20 %
Organism	vertebrates
Reference	Schmid D, Pypaert M, Münz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity. 2007 Jan26(1):79-92. DOI: 10.1016/j.immuni.2006.10.018 p.79 right column top paragraphPubMed ID17182262
Primary Source	See link
Comments	P.79 left column bottom paragraph: "Antigens presented on MHC [major histocompatibility complex] class II are typically exogenous proteins that are endocytosed by the antigen-presenting cell (APC) or endogenous proteins that reside in the secretory system. However, analysis of peptides eluted from MHC class II molecules has revealed that a substantial proportion of natural MHC class II ligands (up to 20%) are derived from cytosolic and nuclear proteins (primary sources)."
Entered by	Uri M
ID	113838