| Comments |
P.205 top paragraph: "Early studies on T-cell responses to allogeneic MHC molecules used the mixed lymphocyte reaction, in which T cells from one individual are mixed with lymphocytes from a second individual. If the T cells of this individual recognize the other individual’s MHC molecules as ‘foreign,’ the T cells will divide and proliferate. (The lymphocytes from the second individual are usually prevented from dividing by irradiation or treatment with the cytostatic drug mitomycin C.) Such studies have shown that roughly 1-10% of all T cells in an individual will respond to stimulation by cells from another, unrelated, member of the same species. This type of T-cell response is called an alloreaction or allreactivity because it represents the recognition of allelic polymorphism in allogeneic MHC molecules." |