Length of peptide used in MHC class 1 antigen presentation

Range 8 - 9 residues
Organism Mammals
Reference Kisselev AF, Akopian TN, Goldberg AL. Range of sizes of peptide products generated during degradation of different proteins by archaeal proteasomes. J Biol Chem. 1998 Jan 23 273(4):1982-9. p.1982 right column 3rd paragraph & p.1989 right colimn 2nd paragraphPubMed ID9442034
Primary Source Goldberg AL, Gaczynska M, Grant E, Michalek M, Rock KL. Functions of the proteasome in antigen presentation. Cold Spring Harb Symp Quant Biol. 1995 60: 479-90.PubMed ID8824421
Comments "In mammalian cells, some of these peptides are utilized in antigen presentation, possibly after further proteolytic processing to the final 8–9- residue peptides presented on the cell surface (primary source)...Analogous studies of product size with eukaryotic proteasomes are also of particular interest because of their role in generating the 8–9-residue peptides used in MHC class 1 antigen presentation (primary source)." Note-value of 8 - 10 residues given by PMID 11350924 p.2357 left column bottom paragraph
Entered by Uri M
ID 109948