Number of somatotroph cells removed daily in euthyroid and hypothyroid rats

Range euthyroid ~22,000: hypothyroid ~9,000 somatotroph cells/day
Organism Rat Rattus norvegicus
Reference DeFesi CR, Astier HS, Surks MI. Kinetics of thyrotrophs and somatotrophs during development of hypothyroidism and L-triiodothyronine treatment of hypothyroid rats. Endocrinology. 1979 Apr104(4):1172-80 DOI: 10.1210/endo-104-4-1172 p.1179 left column 2nd paragraphPubMed ID436756
Method Abstract: "Two experiments were performed to assess the kinetics of changes in somatotroph (St) and thyrotroph (Tt) populations in the rat anterior pituitary after thyroidectomy and during T3 treatment (10 µg/100 g BW) of thyroidectomized rats. St and Tt numbers were determined by a method combining cell counting and determination of DNA in dispersed cells as well as the percentage distribution of cells at the electron microscopic level."
Comments P.1179 left column 2nd paragraph: "If so, the number of St [somatotroph] removed per day in the steady state of euthyroidism or hypothyroidism can be estimated from the product of the total number of St per pituitary in these thyroidal states and the observed fractional disappearance rate of St. These calculations suggest that about 22,000 St are removed per day in euthyroid rats and about 9,000 St are removed per day in hypothyroid rats."
Entered by Uri M
ID 115299