Half-life of a typical mRNA

Range ~32 min
Organism Budding yeast Saccharomyces cerevisiae
Reference Ho B, Baryshnikova A, Brown GW. Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome. Cell Syst. 2018 Feb 28 6(2):192-205.e3. doi: 10.1016/j.cels.2017.12.004 p.202 left column 4th paragraphPubMed ID29361465
Primary Source Geisberg JV, Moqtaderi Z, Fan X, Ozsolak F, Struhl K. Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast. Cell. 2014 Feb 13 156(4):812-24. doi: 10.1016/j.cell.2013.12.026PubMed ID24529382
Comments P.202 left column 4th paragraph: "The apparent absence of a global protein response likely reflects the short half-life of a typical mRNA (~32 min) (primary source) compared with the considerably longer median protein half-life (8.8 hr [Christiano et al., 2014] 2.0 hr [Martin-Perez and Villen, 2015])."
Entered by Uri M
ID 115092