Half-life of typical mRNA

Range ~32 min
Organism Budding yeast Saccharomyces cerevisiae
Reference Brandon Ho et al., Comparative analysis of protein abundance studies to quantify the Saccharomyces cerevisiae proteome, bioRxiv preprint first posted online Feb. 2, 2017, doi: link p.8 left column bottom paragraph
Primary Source Geisberg et al., Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast. Cell. 2014 Feb 13 156(4):812-24. doi: 10.1016/j.cell.2013.12.026PubMed ID24529382
Method Primary source abstract: "[Investigators] measured half-lives of 21,248 mRNA 3' isoforms in yeast by rapidly depleting RNA polymerase II from the nucleus and performing direct RNA sequencing throughout the decay process."
Comments P.8 left column bottom paragraph: "What could account for this apparent discrepancy? First, the half-life of a typical mRNA (~32 minutes) (primary source) is short compared to the typical protein (~43 minutes) (Belle et al. 2006 BNID 104151), and so it might be expected that mRNA levels would show a more rapid response to stress than would protein levels."
Entered by Uri M
ID 114181