Parameters of neurite growth model

Range Table - link
Organism Mammalian tissue culture cell
Reference Tsaneva-Atanasova K, Burgo A, Galli T, Holcman D. Quantifying neurite growth mediated by interactions among secretory vesicles, microtubules, and actin networks. Biophys J. 2009 Feb96(3):840-57. p. 844 table 1PubMed ID19186125
Method Since researchers' model is based on physical properties of the cell, it should, in principle, apply to a wide range of biological systems where protrusions are formed in such a manner. They have indeed applied this approach to neuronal genesis and thus chosen parameter values within the range measured in experimental studies of neuronal cultures or PC12 (rat adrenal medulla) cells. In the case of microtubules assembly/disassembly rates, however, such data is limited therefore, they have taken these rates from in vitro studies with purified tubulin (Fygenson et al., 1994 PMID 9962129)
Comments Researchers have shown here that neurite initiation and growth are based on complex interactions between vesicles, to deliver membrane to the neurite microtubules, to stabilize the neurite and guide the vesicles movement and the actin network that controls the degree of interaction between the microtubules and the neurite.
Entered by Uri M
ID 105558