Parameter values of the model MSO (medial superior olive) neuron in each compartment

Range Table - link
Organism Mongolian gerbil Meriones unguiculatus
Reference Brughera A, Dunai L, Hartmann WM. Human interaural time difference thresholds for sine tones: the high-frequency limit. J Acoust Soc Am. 2013 May133(5):2839-55. doi: 10.1121/1.4795778. p.2843 table IIPubMed ID23654390
Primary Source Fischl, M. J., Combs, T. D., Klug, A., Grothe, B., and Burger, R. M. (2012). “Modulation of synaptic input by GABAB receptors improves coincidence detection for computation of sound location,” J. Physiol. (London) 590, 3047–3066. doi: 10.1113/jphysiol.2011.226233. & Mathews, P. J., Jercog, P. E., Rinzel, J., Scott, L. L., and Golding, N. L. (2010). “Control of submillisecond synaptic timing in binaural coincidence detectors by Kv1 channels,” Nat. Neurosci. 13, 603–609. doi: 10.1038/nn.2530. & Scott, L. L., Mathews, P. J., and Golding, N. L. (2010). “Perisomatic voltage-gated sodium channels actively maintain linear synaptic integration in principal neurons of the medial superior olive,” J. Neurosci. 30, 2039–2050 doi: 10.1523/JNEUROSCI.2385-09.2010. & Zhou, Y., Carney, L. H., and Colburn, H. S. (2005). “A model for interaural time difference sensitivity in the medial superior olive: Interaction of excitatory and inhibitory inputs, channel dynamics, and cellular morphology,” J. Neurosci. 25, 3046–3058.PubMed ID22473782, 20364143, 20147532, 15788761
Comments p.2843 right column top & 2nd paragraph: "A. Neural modeling methods: The model MSO neuron in the computational simulation is defined by its cell and membrane parameters, its input and synaptic parameters, and the acoustic stimuli assumed to drive its inputs. Basic data analysis methods are also defined, and parameter values of the model MSO neuron are provided in Tables II and III. 1. Cell model: The model MSO neuron is based on existing multicompartment Hodgkin-Huxley models for a principal MSO neuron and its ion-channel dynamics (primary sources) with modifications from the primary source Zhou et al. (2005) model described below. The four cylindrical compartments of the model comprise a contralateral dendrite, ipsilateral dendrite, soma, and axon. The two dendrites connect to opposite ends of the soma, and in this study the axon connects to the ipsilateral half of the soma (at 75% of the distance along the soma from its contralateral to ipsilateral end). While the model is used to estimate human ITD [interaural time difference] thresholds, it is based on the physiology of ITD-sensitive MSO neurons in the Mongolian gerbil. To be conservative in predicting a loss in ITD sensitivity at higher frequencies, model parameters were chosen to match or be slightly faster than those measured in the gerbil."
Entered by Uri M
ID 112330