Antibiotic susceptibilities of representative S. enterica serovar Typhimurium SCV (Small Colony Variants) isolates

Range Table - link µg/ml
Organism Bacteria Salmonella enterica
Reference Cano DA, Pucciarelli MG, Martínez-Moya M, Casadesús J, García-del Portillo F. Selection of small-colony variants of Salmonella enterica serovar typhimurium in nonphagocytic eucaryotic cells. Infect Immun. 2003 Jul71(7):3690-8 p.3694 table 3PubMed ID12819049
Method P.3692 left column bottom paragraph: "Antibiotic susceptibility assays. The MIC [Minimum inhibitory concentration] was determined by the E test (AB Biodisk, Solna, Sweden) (ref 61) by following the manufacturer’s instructions."
Comments P.3694 right column bottom paragraph: "The MICs [Minimum inhibitory concentrations] of gentamicin and amikacin for the SCV isolates were increased and were approximately 10-fold higher for the hemL mutant (Table 3). A fourfold increase in the MIC of gentamicin was also noted for the lpd mutant (Table 3). No major differences were observed between the wild type and the SCV in terms of susceptibility to β-lactam antibiotics, chloramphenicol, trimethoprim-sulfamethoxazole, and the quinonoles nalidixic acid and ofloxacin (Table 3). These results suggest that S. enterica SCV isolates are less sensitive to aminoglycosides, an expected finding considering that their mutations may potentially lead to defects in respiratory metabolism. Complementation of the hemL, lpd, and aroD mutants with the corresponding wild-type genes increased antibiotic susceptibility (Table 3), confirming that there is a direct relationship between the point mutations responsible for the SCV phenotype and the observed changes in sensitivity to aminoglycoside antibiotics."
Entered by Uri M
ID 116904