| Comments |
P.38 right column 3rd paragraph: "Phagocytosis, or the internalization of particles by professional phagocytes such as macrophages and dendritic cells, is a critical host defense step during infection with bacteria. Depending on the cell type, a cascade of degradative anti-bacterial processes are initiated by the initial binding and engulfment of pathogens, including the production of superoxide and nitric oxide radicals. Concurrently the newly formed phagosome rapidly acidifies, because of the activity of the vacuolar ATPase (vATPase), a large macromolecular complex that is recruited to the phagosomal membrane. Fusion with lysosomes plays a critical role in this process and results in the delivery of lysosomal hydrolases, or endosomal proteases, that are active in the acidified (pH < 5) lumen of the phagosome." |