Typical extracellular pH of tumor

Range 6.44 - 6.79 unitless
Organism Unspecified
Reference Glunde K, Guggino SE, Solaiyappan M, Pathak AP, Ichikawa Y, Bhujwalla ZM. Extracellular acidification alters lysosomal trafficking in human breast cancer cells. Neoplasia. 2003 Nov-Dec5(6):533-45. p.534 left column 2nd paragraphPubMed ID14965446
Primary Source van Sluis R. et al., In vivo imaging of extracellular pH using 1H MRSI. Magn Reson Med. 1999 41: 743–750.PubMed ID10332850
Comments P.534 left column 2nd paragraph:"Typically, tumor pHe is heterogeneous with a range of 6.44 < pHe < 6.79 [primary source]. The tumor microenvironment plays a critical role in cancer cell invasion and metastasis [refs 29,30], as acidic pH induces invasive, migratory behavior in vitro [ref 30] and metastasis in vivo [ref 31], through the activation and release of proteases from cancer cells [refs 32–35]." Keywords:acidity,oncology,tumorigenesis
Entered by Uri M
ID 112107