| Range |
euthyroid ~9,900: hypothyroid ~45,000 somatotroph cells/day
|
| Organism |
Rat Rattus norvegicus |
| Reference |
DeFesi CR, Astier HS, Surks MI. Kinetics of thyrotrophs and somatotrophs during development of hypothyroidism and L-triiodothyronine treatment of hypothyroid rats. Endocrinology. 1979 Apr104(4):1172-80 DOI: 10.1210/endo-104-4-1172 p.1179 left column 3rd paragraphPubMed ID436756
|
| Method |
Abstract: "Two experiments were performed to assess the kinetics of changes in somatotroph (St) and thyrotroph (Tt) populations in the rat anterior pituitary after thyroidectomy and during T3 treatment (10 µg/100 g BW) of thyroidectomized rats. St and Tt numbers were determined by a method combining cell counting and determination of DNA in dispersed cells as well as the percentage distribution of cells at the electron microscopic level." |
| Comments |
P.1179 left column 3rd paragraph: "From the product of the average rate of decrease for TSH cells (3.3%/day) and the number of these cells per pituitary in the steady state settings of euthyroidism and hypothyroidism
(ref 11), [investigators] estimate that about 9,900 and 45,000 TSH cells are removed per day in the euthyroid and hypothyroid states, respectively." |
| Entered by |
Uri M |
| ID |
115300 |