| Comments |
P.236 left column 4th & 5th paragraphs: "Flaky skin: Flaky skin, often called “dry” skin, is a cutaneous reaction pattern reflecting abnormal desquamation of diverse etiologies. Corneocytes are normally shed in small enough groups that they are not visible on the skin surface-when this process is disturbed in any way, corneocytes collect in visible clumps (scales) that produce a rough texture and appearance. The importance of SC water content to “normal” nonflaky skin appearance has long been known, with healthy tissue containing greater than 10% water (primary sources). Both water soluble intracorneocyte substances (collectively referred to as natural moisturizing factor (NMF)) (reviewed in Harding et al, 2000) and the intercellular lipid membranes (Imokawa et al, 1991) contribute to the water binding properties of the SC and the barrier properties of the intercellular membranes maintain hydration by limiting water loss from the tissue." |