Fraction of all genes that are regulated by at least one miRNA

Range ~20-30 %
Organism Unspecified
Reference Malan-Müller S, Hemmings SM. The Big Role of Small RNAs in Anxiety and Stress-Related Disorders. Vitam Horm. 2017 103: 85-129. doi: 10.1016/bs.vh.2016.08.001. p.91 2nd paragraphPubMed ID28061977
Primary Source D.P. Bartel MicroRNAs: Genomics, biogenesis, mechanism, and function Cell, 116 (2004), pp. 281–297 AND A. Krek, D. Grun, M.N. Poy, R. Wolf, L. Rosenberg, E.J. Epstein, et al. Combinatorial microRNA target predictions Nature Genetics, 37 (2005), pp. 495–500 DOI: 10.1038/ng1536 AND B.P. Lewis, I.H. Shih, M.W. Jones-Rhoades, D.P. Bartel, C.B. Burge Prediction of mammalian microRNA targets Cell, 115 (2003), pp. 787–798 AND C. Volonté, S. Apolloni, C. Parisi MicroRNAs: Newcomers into the ALS picture CNS & Neurological Disorders: Drug Targets, 14 (2015), pp. 24–32PubMed ID14744438, 15806104, 14697198, 25613506
Comments P.91 2nd paragraph: "Approximately 20–30% of all genes are regulated by at least one miRNA (primary sources). In addition, a single miRNA can target hundreds of genes and one gene can also be targeted by more than one miRNA (Wang, Li, & Hu, 2011)."
Entered by Uri M
ID 113092