Fraction of autosomal genes involved with sexually dimorphic patterns of gene expression

Range ≤60 %
Organism Human Homo sapiens
Reference Gershoni M, Pietrokovski S. The landscape of sex-differential transcriptome and its consequent selection in human adults. BMC Biol. 2017 Feb 7 15(1):7. doi: 10.1186/s12915-017-0352-z. p.10 left column 4th paragraphPubMed ID28173793
Primary Source [56] Chen et al., Sexual dimorphism in gene expression and regulatory networks across human tissues. bioRxiv 2016. Epub ahead of print. doi:10.1101/082289. link
Method P.2 right column top paragraph: "Here, by rigorous analysis of RNA-sequencing (RNA-seq) data from the GTEx [Genotype-Tissue Expression] project [refs 27, 28], [investigators] have comprehensively mapped, for the first time, human adults sex-differential gene expression over 45 tissues common to both sexes. [They] then identified highly and moderately sex-specific genes while considering the complete panel of 53 tissues."
Comments p.10 left column 4th paragraph: "After submitting this work for review, two studies on sexual dimorphism in human gene expression were made public. Kassam et al. examined the sex-specific genetic architecture of autosomal gene expression in whole blood samples from about one thousand men and one thousand women using DNA arrays [ref 55]. No differences between men and women were found in autosomal genetic control of gene expression. [Investigators] too did not identify autosomal genes with different expression between men and women in the GTEx whole blood tissue (Fig. 1, Additional file 3: Table S1). Chen et al. posted to bioRxiv a non-peer-reviewed preprint analyzing the GTEx data for gene expression sexual dimorphism and regulatory networks [primary source]. They report sexually dimorphic patterns of gene expression involving as many as 60% of autosomal genes. Similar to [their] findings, they reported breast, skin, adipose, heart, and skeletal muscle as the most sexually dimorphic tissues. The studies vary in their analyses procedures and emphasize different contexts of SDE [Sex-differentially expression]. These studies are complementary works with different insights."
Entered by Uri M
ID 113475