| Comments |
P.10 2nd & 3rd paragraphs: "Table 3 collects the changes to each of the previously mentioned parameters for individuals that represent different segments of the human population: reference adult woman (1.63 m, 60
kg [ref 39]), young infant (age 4 weeks), infant (age 1 year), elder (66 years), and obese (140 kg). Review of the literature shows no significant effect on the colonic bacterial concentrations over age from the one month old infant to the elderly [primary source 40, ref 41]. The colonization of the neonatal GI tract from negligible colon bacterial concentrations of ≤10^5 bacteria/mL to concentrations equivalent to those of adults occurs in just under one month [ref 42]. For this dynamic period that is yet to be charted in high resolution, [investigators] do not supply a B/H ratio estimate. As with age, extremes of weight have low impact on bacterial cell counts. [primary source 43]. The reported values for infants and obese are in the range of variation of “the reference man.” In addition, [they] could not find any report in the literature on gender-specific differences in bacteria density in the colon. As can be appreciated from Table 3, the B/H ratio varies by up to 2-fold across those different population groups from a low of 1.3 to a high of 2.3." See notes beneath table |