| Range |
in macaque lymphoid tissue 5.5/day: in human blood 23/day days^-1
|
| Organism |
HIV |
| Reference |
De Boer RJ, Ribeiro RM, Perelson AS. Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. PLoS Comput Biol. 2010 Sep 2 6(9):e1000906. doi: 10.1371/journal.pcbi.1000906. p.2 right column 3rd paragraphPubMed ID20824126
|
| Primary Source |
[15] Ramratnam B, Bonhoeffer S, Binley J, Hurley A, Zhang L, et al. (1999) Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 354: 1782–1785. [23] Reilly C, Wietgrefe S, Sedgewick G, Haase A. Determination of simian immunodeficiency virus production by infected activated and resting cells. AIDS. 2007 Jan 11 21(2):163-8. [24] Chen HY, Di Mascio M, Perelson AS, Ho DD, Zhang L (2007) Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques. Proc Natl Acad Sci USA 104: 19079–19084.PubMed ID10577640, 17197806, 18025463
|
| Comments |
P.2 right column 3rd paragraph: "Summarizing, the latest production rate estimates converge on a few thousand to approximately 5×10^4 virions per productively infected cell [ref 22 primary sources 23, 24]. The production rate estimates of Reilly et al. and Chen et al. depend on the viral clearance rate, c. The 10-fold range in the estimated production rates is at least partly due
to differences in the clearance rate used in the calculations. Reilly et al. [primary source 23] estimate that c=5.5 d^-1 in lymphoid tissue, while Chen et al. [primary source 24] used a previous estimate of c=23 d^-1 in the blood [primary source 15]. Since, [investigators’] main result will be that the clearance of free virus in lymphoid tissue should be fast, and that the observed clearance from the blood is not clearance but the rate of efflux to other organs, [they] will vary the production rate in [their] analysis and
consider 10^3 to 5×10^4 particles per cell as potential realistic estimates. Finally, note that different cell types, e.g., infected macrophages, may have different production rates than infected T cells. Here [they] consider that the vast majority of virus is produced by infected CD4+ T-cells [refs 4,25], and hence use estimates of production from those cells." |
| Entered by |
Uri M |
| ID |
112649 |