| Range |
productively infected CD4+ T cells 10^8 cells: total number of HIV-1 particles >5×10^10 particles
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| Organism |
HIV |
| Reference |
De Boer RJ, Ribeiro RM, Perelson AS. Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. PLoS Comput Biol. 2010 Sep 2 6(9):e1000906. doi: 10.1371/journal.pcbi.1000906. p.1 left column top paragraphPubMed ID20824126
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| Primary Source |
[5] Haase AT, Henry K, Zupancic M, Sedgewick G, Faust RA, et al. (1996) Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274: 985–989. [6] Chun TW, Carruth L, Finzi D, Shen X, DiGiuseppe JA, et al. (1997) Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387: 183–188.PubMed ID8875941, 9144289
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| Comments |
P.1 left column top paragraph: "Introduction: The major targets of HIV and simian immunodeficiency virus (SIV) infection are CD4+ T cells [ref 1]. During the acute stage of infection large numbers of resting and memory CD4+ T cells disappear from the lymphoid tissues and mucosal layers,
particularly in the gut, by direct infection and by bystander effects. Lymphoid tissue remains the primary site of infection after acute infection has resolved and the viral load approaches a steady state called the ‘‘set-point’’ [ref 1]. Chronic infection is characterized by a set-point viral load, and rapid turnover of productively infected cells [refs 2–4]. To maintain this steady state requires a balance between virus production and clearance, and between
target cell production and death. Combining image analysis with in situ hybridization in lymphoid tissue from patients chronically infected with HIV-1, the total number of productively infected CD4+ T cells has been estimated to be 10^8 cells, and the total number of HIV-1 particles has been estimated to exceed 5×10^10 virions [primary sources]. At steady state, one could naively conclude that a
single productively infected CD4+ T cell should therefore account for a viral load of approximately 500 virions. [Investigators] shall show below that the situation is more complex." |
| Entered by |
Uri M |
| ID |
112644 |