| Range |
both vacuolated-columnar and goblet cells ~5: deep crypt secretory cell ~14 - 21 days
|
| Organism |
Mouse Mus musculus |
| Reference |
Karam SM, Lineage commitment and maturation of epithelial cells in the gut. Front Biosci. 1999 Mar 15 4: D286-98. p.286 right column top paragraph, p.294 right column top paragraph & right column 2nd paragraphPubMed ID10077541
|
| Primary Source |
[19] W.W.L. Chang & C.P. Leblond: Renewal of the epithelium in the descending colon of the mouse. I. Presence of three cell populations: vacuolated-columnar, mucous and argentaffin. Am J Anat 131, 73-100 (1971) [21] G.G. Altmann: Renewal of intestinal epithelium: New aspects as indicated by recent ultrastructural observations. J Elec Mic Tech 16, 2-14 (1990)PubMed ID4103773, 1698949
|
| Comments |
P.286 right column top paragraph:"In the crypts of the descending colon, both vacuolated-columnar and goblet cells migrate outwards and for each the turnover time is about 5 days. The ascending colon has an additional cell type called deep crypt secretory cells which migrate inwards and their turnover time is about 14-21 days." P.294 left column bottom paragraph:"Goblet cells are located in the upper third (or two thirds) of the ascending (or descending) colon. The mucous granules are large and numerous and thus, the theca is swollen to give a typical goblet appearance. The dark nuclei are squeezed at the base of the goblet. In the descending colon, it takes about 1 day for a goblet cell to migrate along one third of the crypt and reach the surface. The overall turnover time of goblet cells is similar to that of the vacuolated-columnar cells it averages 4.6 days (primary source 19)." P.294 right column 2nd paragraph:"Deep crypt secretory cell lineage-Members of this lineage are found in several species including mice, rats as well as humans. They differ from goblet cells in location, histochemistry and ultrastructure (ref 20). They lack the goblet-shaped theca, but exhibit many mucous granules which appear large and light in mice and rats, but small and dark in humans (primary source 21). These cells are produced from stem cells located in the mid crypt as pre-deep crypt secretory cells and undergo migration-associated differentiation. They reach the crypt bottom as mature deep crypt secretory cells. In mice, they have an average turnover time of about 14-21 days (primary source 21)." |
| Entered by |
Uri M |
| ID |
112307 |