Average turnover time of pit, zymogenic and parietal cells in oxyntic pit-gland unit in stomach

Range pit 3: zymogenic 194: parietal 54 days
Organism Mouse Mus musculus
Reference Karam SM, Lineage commitment and maturation of epithelial cells in the gut. Front Biosci. 1999 Mar 15 4: D286-98. p.286 left column, p.291 left column top paragraph, p.291 right column 2nd paragraph & p.292 left column top paragraphPubMed ID10077541
Primary Source [43] S.M. Karam & CP Leblond: Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cells. Anat Rec 236, 280-96 (1993) [45] S.M. Karam & C.P. Leblond: Dynamics of epithelial cells in the corpus of the mouse stomach. III. Inward migration of neck cells followed by progressive transformation into zymogenic cells. Anat Rec 236, 297-313 (1993) [49] S.M. Karam: Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss. Anat Rec 236, 314-32 (1993)PubMed ID8338233, 8338234, 8338235
Comments P.286 left column:"In the stomach, the oxyntic pit-gland unit includes pit, zymogenic and parietal cells which respectively migrate outwards, inwards, and in both directions their turnover times average 3, 194 and 54 days, respectively." p.291 left column top paragraph:"The overall turnover time of pit cells averages 3 days (primary source 43)." p.291 right column 2nd paragraph:"Zymogenic cells are end cells which eventually acquire signs of degeneration and finally die at the gland bottom after a long turnover time of ~194 days (primary source 45)." p.292 left column top paragraph:"Young parietal cells in the isthmus and neck are more active than old parietal cells in the pit and base regions. The estimated turnover time of parietal cells is about 54 days (primary source 49)."
Entered by Uri M
ID 112304