Halflife of olfactory sensory neurons

Range ~90 days
Organism Mouse Mus musculus
Reference Gogos JA, Osborne J, Nemes A, Mendelsohn M, Axel R. Genetic ablation and restoration of the olfactory topographic map. Cell. 2000 Nov 10 103(4):609-20. abstract & p.609 right column top paragraphPubMed ID11106731
Primary Source [18] P.P.C. Graziadei, G.A. Monti Graziadei Continuous nerve cell renewal in the olfactory system. M. Jacobsons (Ed.), Development of Sensory Systems, Berlin, New York, Springer-Verlag (1978) 55–82.pp [19] J.W. Hinds, P.L. Hinds, N.A. McNelly An autoradiographic study of the mouse olfactory epithelium: evidence for long-lived receptors Anat. Rec., 210 (1984), pp. 375–383 [26] A. Mackay-Sim, P. Kittel Cell dynamics in the adult mouse olfactory epithelium: a quantitative autoradiographic study J. Neurosci., 11 (1991), pp. 979–984 a [27] A. Mackay-Sim, P.W. Kittel On the life span of olfactory receptor neurons Eur. J. Neurosci., 3 (1991), pp. 209–215 bPubMed ID6542328, 2010818, 12106197
Comments Abstract:"Olfactory sensory neurons have a half-life of about 90 days and are continually renewing." p.609 right column top paragraph:"In the adult mouse, olfactory sensory neurons turn over asynchronously with a half-life of about 90 days (primary sources). Regenerating neurons derive from dividing olfactory stem cells, the globose basal cells, that reside at the base of the sensory epithelium (Caggiano et al. 1994). The topographic map of sensory projections in the olfactory bulb remains constant with age despite the continual generation of sensory neurons, implying that information necessary for maintenance of the map persists throughout the life of the organism."
Entered by Uri M
ID 111746