Fraction of the ancestral genome lost over the course of 35 years in the lungs of human patients with cystic fibrosis

Range ≤8 %
Organism Bacteria Pseudomonas aeruginosa
Reference Raeside C, et al., Large chromosomal rearrangements during a long-term evolution experiment with Escherichia coli. MBio. 2014 Sep 95(5):e01377-14. doi: 10.1128/mBio.01377-14. p.7 right column bottom paragraphPubMed ID25205090
Primary Source Rau MH, Marvig RL, Ehrlich GD, Molin S, Jelsbak L. 2012. Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment. Environ. Microbiol. 14:2200–2211. doi: 10.1111/j.1462-2920.2012.02795.x.PubMed ID22672046
Comments "On a time scale more commensurate with the LTEE [long-term evolution experiment], a study of P. aeruginosa adapting to the lungs of human patients with cystic fibrosis found that up to 8% of the ancestral genome was lost over the course of 35 years (primary source), in that study, the average and median deletion sizes were 44.5 kbp and 26.6 kbp, respectively, for 27 deletion events with sizes of at least 1 kbp. Most deletions in the P. aeruginosa study occurred through illegitimate and homologous recombination events, but IS [insertion sequence] elements were not involved."
Entered by Uri M
ID 111499