Fraction of of the large-scale rearrangements detected in evolved clones that occurred by homologous recombination between IS [insertion sequence] elements

Range ~70 %
Organism Bacteria Escherichia coli
Reference Raeside C, et al., Large chromosomal rearrangements during a long-term evolution experiment with Escherichia coli. MBio. 2014 Sep 95(5):e01377-14. doi: 10.1128/mBio.01377-14. p.9 right column bottom paragraphPubMed ID25205090
Method p.2 right column 2nd paragraph:"[Investigators] produced optical chromosomal maps for clones isolated from a long-term evolution experiment (LTEE) with E. coli. In this ongoing experiment, 12 populations have been independently propagated from a common ancestor in the same glucose-limited minimal medium for more than 25 years and 50,000 cell generations."
Comments "About 70% of the large-scale rearrangements [investigators] detected in the evolved clones occurred by homologous recombination between IS elements, and that proportion does not include new insertions of IS elements (because optical mapping cannot resolve such events)."
Entered by Uri M
ID 111500