Fraction of cells that have duplications, inversions, and small deletions after 50 generations

Range ≥20 % of all cells
Organism Bacteria Salmonella typhimurium
Reference Raeside C, et al., Large chromosomal rearrangements during a long-term evolution experiment with Escherichia coli. MBio. 2014 Sep 95(5):e01377-14. doi: 10.1128/mBio.01377-14. p.2 left column 3rd paragraphPubMed ID25205090
Primary Source Sun S, Ke R, Hughes D, Nilsson M, Andersson DI . 2012. Genome-wide detection of spontaneous chromosomal rearrangements in bacteria. PLoS One 7:e42639. doi:10.1371/journal.pone.0042639.PubMed ID22880062
Method Whole-genome sequencing
Comments "Large-scale rearrangements occur spontaneously at measurable frequencies, although the rates at which they occur are uncertain. In an older study, duplications were reported to arise at frequencies of between 10^-2 and 10^-5 per cell division, depending on their chromosomal location (BNID 111496). A more recent whole-genome sequencing study (primary source) of a population of S. enterica var. Typhimurium that was propagated in a chemostat found duplications, inversions, and small deletions in =20% of the cells after only 50 generations."
Entered by Uri M
ID 111497