Median turnover number for the entire data set of enzymes and natural substrates
| Range | ~10 sec^-1 |
|---|---|
| Organism | Generic |
| Reference | Bar-Even A. et al., The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters. Biochemistry. 2011 May 31 50(21):4402-10. doi: 10.1021/bi2002289. p.4403 right column 3rd paragraphPubMed ID21506553 |
| Method | "Here [investigators] describe a global view of enzyme parameters with the aim of highlighting the forces that shape the catalytic efficiency of enzymes." |
| Comments | "The median turnover number for the entire data set of enzymes and natural substrates is ~10 s^-1 (Figure 1A), where most kcat values (~60%) are in the range of 1-100 s^-1. These rates are orders of magnitude slower than the textbook examples of fast enzymes [e.g., carbonic anhydrase (Figure 1A)], let alone compared to the theoretical limit of 10^6-10^7S^-1. [refs 6,1]" |
| Entered by | Uri M |
| ID | 111411 |