| Comments |
[40% phosphatidylcholine,32%phosphatidylethanolamine,12% phosphatidylserine, 5% phosphatidylinositol, 10% cholesterol, wt/wt] "Synaptic vesicles are uniformly small (~20-nm radius), abundant organelles whose
only known function is to take up and release neurotransmitters. They are relatively
simple because only a limited number of proteins fit into a sphere of 40-nm diameter.
Purified vesicles have a protein:phospholipid ratio of 1:3 with an unremarkable
lipid composition (40% phosphatidylcholine,32%phosphatidylethanolamine,12%
phosphatidylserine, 5% phosphatidylinositol, 10% cholesterol, wt/wt Primary Source). Many proteins that have been associated with synaptic vesicles are
probably present only on a subset of vesicles or bind transiently to the vesicles,
and the number of proteins that are constitutive parts of all synaptic vesicles may
be comparatively small (i.e., less than 50)." |