| Range |
colorectal cancer 25y: leukemias 7y: uterine cancer 10y years
|
| Organism |
Human Homo sapiens |
| Reference |
Tomasetti C, Vogelstein B, Parmigiani G. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A. 2013 Feb 5 110(6):1999-2004. doi: 10.1073/pnas.1221068110. p.2000 right column 3rd paragraphPubMed ID23345422
|
| Primary Source |
(2) Jones S, et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 105(11):4283–4288. (14) Bizzozero OJ, Jr., Johnson KG, Jr., Ciocco A (1966) Radiation-related leukemia in Hiroshima and Nagasaki, 1946-1964. I. Distribution, incidence and appearance time. N Engl J Med 274(20):1095–1101. (15) Little MP (2009) Cancer and non-cancer effects in Japanese atomic bomb survivors. J Radiol Prot 29(2A):A43–A59.PubMed ID18337506, 5932020, 19454804
|
| Comments |
"What fraction of somatic mutations in a tumor actually arises
in the precursor cells before tumor initiation? The number (and
fraction) of mutations that occurred before tumor initiation can
be estimated by subtracting the number of mutations that occurred
during tumor progression (the tail of the fish) from the
total number. To estimate this value, [researchers] need to know the average
time it takes for a tumor to reach detection size. It has been estimated
that colorectal cancer requires an average of 25 y (primary source 2),
whereas leukemias take 7 y (primary source 14). For uterine cancer a value of
10 y is assumed (primary source 15)." |
| Entered by |
Uri M |
| ID |
111247 |