Fraction of of colitis-associated tumors in which allelic deletion of p53 was observed

Range 50-80 %
Organism Human Homo sapiens
Reference Ullman TA, Itzkowitz SH. Intestinal inflammation and cancer. Gastroenterology. 2011 May140(6):1807-16. p.1810 right column bottom paragraphPubMed ID21530747
Primary Source [25] Burmer GC et al., Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele. Gastroenterology. 1992 Nov103(5):1602-10. [26] Yin J et al., p53 point mutations in dysplastic and cancerous ulcerative colitis lesions. Gastroenterology. 1993 Jun104(6):1633-9.PubMed ID1358743, 8500720
Comments P.1810 right column bottom paragraph: "Loss of p53 function is an important step in progression of colitis-associated cancer. Allelic deletion of p53 was observed in approximately 50%–85% of colitis-associated tumors [primary sources]."
Entered by Uri M
ID 106629