Average number of somatic mutations in cancers of patients of various age

Range Table - link mutations/patient
Organism Human Homo sapiens
Reference Tomasetti C, Vogelstein B, Parmigiani G. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A. 2013 Feb 5 110(6):1999-2004. doi: 10.1073/pnas.1221068110. p.2001 table 1PubMed ID23345422
Comments "The average number of somatic mutations in patients of various ages can be estimated by the regressions depicted in Fig. 2 (Materials and Methods). As shown in Table 1, it is substantially higher in 85-y-old patients than in 25-y-old patients: 24.16 vs. 10.09 (CLL), 96.48 vs. 45.96 (uterine), and 121.38 vs. 50.2 (colorectal), consistent with [researchers'] model’s prediction." CLL=chronic lymphocytic leukemia
Entered by Uri M
ID 111249