| Comments |
"[Researchers] present the first detailed kinetic model of human hepatic
glucose metabolism integrated with the hormonal regulation via
insulin, glucagon and epinephrine (Figure 1 and Methods) via a
new concept of changes in phosphorylation state (Figure 2 and
Methods). The model was validated with quantitative and
qualitative experimental data from a multitude of studies on
hepatic glucose metabolism in overnight fasting, short term fasting
and postprandial glycogen storage (Table 3, Figure 3, Figure 4, Dataset S1)." |