Permeability of red blood cell membrane to CO2

Value 0.0075 cm/sec
Organism Rat Rattus norvegicus
Reference Forster RE, Gros G, Lin L, Ono Y, Wunder M. The effect of 4,4'-diisothiocyanato-stilbene-2,2'-disulfonate on CO2 permeability of the red blood cell membrane. Proc Natl Acad Sci U S A. 1998 Dec 22 95(26):15815-20. p.15818 left column bottom paragraphPubMed ID9861053
Primary Source Silverman DN, Tu CK, Roessler N. Diffusion-limited exchange of 18O between CO2 and water in red cell suspensions. Respir Physiol. 1981 Jun44(3):285-98.PubMed ID6791257
Comments "Silverman and colleagues reported studies on 18O exchange of rat red cell suspensions in a series of stimulating papers from 1974 to 1981 (refs 5, 13–14 and primary source). Their final conclusion was that diffusion resistance across the red cell membrane, rather than the intracellular CA [carbonic anhydrase] activity rate, limited CO2 exchange. The value of Pm,CO2 that they obtained in rat red cells was 0.0075 cm/sec (primary source), at least two orders of magnitude less than the approximate value for normal human red cells [BNID 110615] in Table 1, [Table - link ]."
Entered by Uri M
ID 110617